Today is a very important day for our PRIMA programme and for the Research and Cooperation system of the Mediterranean Area. After 6 years of intense work, thanks to a strong political and technical commitment by all Participating States and EU Institutions, we are now ready for the launch of the PRIMA calls 2018. The Delegation Agreement among EC and the PRIMA Foundation has been signed concluding with success the intense phase of preparation of the PRIMA programme, also thank to the efforts and commitment of the PRIMA Secretariat. Today, PRIMA Calls 2018 will be opened in the www.prima-med.org website (http://prima-med.org/calls-for-proposals/) We believe that this is the beginning of a new phase, with the aim of building a stronger base of excellent scientific activities in the water and food sectors, able to define solutions supporting communities, consumers and enterprises to deal with Mediterranean environmental and social challenges, and to build cooperation among researchers and innovators in the Area. Prof. Angelo Riccaboni, Università di Siena Chair, Fundación PRIMA